Mercury causes significant destruction of stomach and
intestine
epithelial cells, resulting
in damage to stomach lining which along
with
mercury’s ability to bind
to SH hydroxyl radical in cell membranes
alters permeability
(338,405,35,21c) and adversely alters bacterial
populations in the
intestines causing leaky gut syndrome with toxic,
incompletely digested
complexes in the blood (116,228b,35) and
accumulation of heliobacter
pylori, a suspected major factor in
stomach ulcers and stomach
cancer (256) and Candida albicans, as
well as poor nutrient
absorption (338,3).
Dental amalgam has been found to be
the largest source of mercury exposure in most people who have several amalgam
fillings(7). Replacement of amalgam
fillings and metals detoxification have been found to significantly improve the
health of most with conditions related
to bowel dysfunction and leaky gut syndrome(8,9).
Other common causes or factors in leaky gut and the related
conditions include food allergies and intolerances;
drugs(NSAIDs,
aspirin, stomach h2 blockers, steroids,etc.);
Dysbiosis( overgrowth of
harmful organisms due to antibiotic use and/or low
probiotic
levels); chronic alcohol consumption; toxic exposures and
chemical
sensitivity; chronic infections; inadequate digestive enzymes
(6b)
While
food allergies mediated by IgE can cause significant health
effects including leaky gut syndrome, these are
usually easily
identified by the immediateness of reactions or
skin tests. Food
intolerances mediated by IgG also commonly cause
significant health
effects including leaky gut syndrome, but the
reactions are delayed
and can be systemic and are harder to identify.
Tests based on IgE
such as skin test or RAST do not reliably identify
such problems that
are common factors in chronic health conditions and
tests such as
ELISA that measure both IgE and IgG are more
reliable. Common
causes of food intolerances include failure to breast
feed babies for at
least the first year of life, feeding table food in
first year of life, use of
antibiotics without adequate addition of probiotics;
eating the same
foods every day(6b). Food intolerances and food
additives or
processed foods that contain glutamate, aspartame,
high-fructose corn
syrup, dyes, etc. are common causes of leaky gut
syndrome and
neurological conditions such as ADHD(6b).
Food
intolerances and IgG reactions lead to long lasting
“immune
complexes” that are factors in leaky gut related conditions
as well as
conditions such as Lupus, rheumatoid arthritis,
ADHD, etc. Inflammatory
reactions to toxic metals, vaccines, food
additives, food intolerances not only cause immune reactions
but also
reactions in the neurological microglial
system. This can cause brain
fog, memory problems, and degenerative neurological
conditions if
prolonged chronic exposures(6). For example virtually 100%
of those
with schizophrenic symptoms in schizophrenia, autism,
ADHD, are
found when tested to have food intolerance to wheat
gluten or milk
casein(6bd).
Enzymatic blockages by chronic toxic metal exposures
such as vaccines or mercury have been found to be a
factor in these
food intolerances.
Similarly this is the most common cause or factor
in celiac disease and common cause of ataxia and
diabetes(6bde).
Similarly food allergies or additives, food
intolerances, high sugar
consumption, and antibiotic use with adequate probiotics have been
found to be the most common causes of children’s ear
infections.
Clinical studies have found that diets high in flavanoids, cartenoids,
and including nutritional supplements such as buffered
Vit C and
natural E, selenium, omega-3 oils, probiotics
are effective in
preventing ear infections and other chronic conditions(6b).
These in
addition to multiple B vitamins, the flavanoids
curcumin, hesperidin,
and quercetin are effective
in preventing and treating leaky gut related
conditions(6).
Supplements
and other
treatments that reduce intestinal
permeability have also been found to be protective against and
to
improve these conditions. Glutamine, berberine,
probiotics, and
vitamin D have been found to decrease intestinal
permeability and
protect against effects caused by leaky gut syndrome(4,5).
Butyrate
has been found to inhibit inflammation and
carcinogenesis in the
intestines and low butyrate levels are found in colon cancer,
ulcerative
colitis and crohn’s disease(10).
Butyrate and phosphatidylcholine have
been found to be protective against these conditions,
and increased
fiber content in diet promotes increased butyrate
levels, through the
effect on fermentation pattern(10).
Brain
inflammation or hypoglycemia related to toxic metal
exposures, food intolerances, etc. have been found to be
common
causes of ADHD, impulsivity, juvenile delinquency, criminality,
and
violence(6b,11).
Mercury forms strong bonds with and
modification of the-SH
groups of proteins causing mitochondrial release of
calcium (20,21,35,
43,329,333,432), as well as altering molecular
function of amino acids
and damaging enzymatic
process(33,96,111,194,252,338,405,410-
412), resulting in improper cysteine regulation (194), inhibited
glucose transfer and uptake(338,254), damaged sulfur
metabolism
and oxidation processes (33,194,338), autoimmune
effects(126,43),
and reduced glutathione
availability (necessary for detoxification)
(13,111,194,54). All types of cells exhibited a
dose dependent
reduction in cellular glutathione when exposed to
mercury,
inhibiting generation of
HgCl2 also inhibits
aquaporin‑mediated water transport in red blood
cells(479), as well as
oxygen transport by hemoglobin(232).
Mercury from amalgam is methylated by bacteria
and candida albicans in the mouth and intestines (51,225,506). The level of
organic mercury in saliva is significantly related to the number of amalgam
fillings(506). High levels of Vit B12 in
the system also have been found to result in increased methyl mercury
concentrations in the liver and brain (51c).
Occupational exposure studies have found mercury
impairs the body’s
ability to kill Candida albicans by impairment of the
lytic activity of
neutrophils and myeloperoxidase in
workers whose mercury excretion
levels are within current safety
limits(285,404,467). Such levels of
mercury exposure were also found to inhibit cellular
respiratory burst.
A population of plant workers with average mercury
excretion of 20
ug/g creatinine was found to
have long lasting impairment of
neutrophil function(285,404). Immune Th1 cells inhibit candida by
cytokine related activation of macrophages and neutrophils.
Development of Th2 type immune responses deactivate
such defenses
(404b). Mercury inhibits macrophage and neutrophil defense against
candida by its affects on Th1 and Th2 cytokine
effects(181,285). Low
doses also induced autoimmunity in some
species(181,314,369,404,
405,43). Candida overgrowth results in production of
the highly
toxic canditoxin and ethanol
which are known to cause fatigue,
toxicity, and depressive symptoms(46). Another study(59) found such
impairment of neutrophils decreases
the body’s ability to combat
viruses such as those that cause heart damage, resulting
in more
inflammatory damage.
Another group of workers with average
excretion rates of 24.7 ug/ g creatinine had long lasting increases in
humoral immunological stimulation of IgG,
IgA, and IgM levels.
. The immune suppression caused by exposure to
mercury or other
toxics has also be found to increase susceptibility to
other common
pathogens such as viruses, mycoplasma,
bacteria, candida, and
parasites (469b,470,485). The majority of those tested with
autoimmune conditions such as
to be infected with mycoplasma(470)
and similar for parasites(485).
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