Cancer
Connection to Mercury, Toxic Metals, and Dental Cavitations B
Medical
labs, medical studies, and government agencies have documented that dental
amalgam is the largest source of mercury in most people who have several
amalgam fillings (1). Fish, vaccinations, and occupational exposure such as
dental offices are other sources of significant mercury exposures. A nationwide
survey found that over 22 percent of those tested for mercury levels in the
hair had dangerous levels higher than the U.S. EPA mercury health reference
level(2). Toxic metal
levels were measured in 6-24 hours urinary samples of 100 randomly chosen
patinets with chronic conditions at the Institute of Integrative Medicine
following a combined EDTA/DMSA provocation challenge. Over 70% had levels of lead, arsenic,
mercury, or cadmium outside the Laboratory Reference Level(571).
A large U.S. Centers for Disease Control
epidemiological study, NHANES
Mercury
and other toxic metals such as copper and lead cause breaks in
Nobel
Prize winner Dr. Otto Warburg determined that cancer
has only one prime cause (581). It is the replacement of normal oxygen
respiration of the body's cells by an anaerobic [i.e., oxygen-deficient] cell
respiration. Porphyrins are
precursors to heme, the oxygen
carrying component of blood. Mercury
inhibits the conversion of specific porphyrins to heme.
(84,35,201,539) Mercury has been documented to bind to oxygen carrying sites in
the blood, reducing a person’s available oxygen supply. (232,233,570,571). Mercury
binds with hemoglobin, which is located inside the red blood cell and carries
oxygen for transport to tissues. Mercury bound to hemoglobin results in less
oxygen carrying capacity of the red blood cell and therefore less oxygen will
reach the tissues. The body senses the need for more oxygen and may attempt to
compensate for this by increasing the production of hemoglobin. A normal or increased hemoglobin level combined
with symptoms of lack of oxygen (fatigue, weakness, appearing pale, rapid heart
rate, shortness of breath, etc) could indicate mercury toxicity. But this can
confuse some doctors since the patient seems like they are anemic but in fact
the blood counts seem fine (233).
At the energetic-molecular level,
the boundary between health and the state of absence of health is marked by
oxidosis, acidosis, and dysoxygenosis (dysox). (571,581) There
is but one fundamental difference between a healthy cell and an unwell cell: a
healthy cell has a well preserved oxygen homeostasis. A healthy cell utilizes
oxygen well, without incremental oxidative stress (oxidosis)
and without accumulating organic acids (acidosis). In contrast, an unwell cell cannot utilize oxygen well and gets clogged up
with Krebs cycle metabolites and other organic acids. At the bioenergetic cellular level, all inflammatory, autoimmune,
and neurodegenerative disorders are caused by the oxygen disorder
(dysfunctional oxygen utilization) caused by cellular toxicity in the cells.
Mercury from dental amalgams
appears to be one of the most, if not the most, potent disrupters of oxygen
metabolism in the oral cavity(571,233). Other such disrupters are thioethers
related to root canal teeth or cavitations and other microbial toxins . Those
factors also alter the local conditions that either inhibit or foster microbial
growth, so facilitating biofilm formation. Such dynamics seem to play crucial
roles in the pathogenesis of systemic disorders rooted in the oral cavity. The crucial importance of oral toxicity in
triggering, amplifying, and perpetuating systemic inflammatory and infectious
disorders has largely been ignored by most doctors and dentists. The
presence of the cellular dysox state can be readily
documented by the measurement of 24-hour urinary excretion of organic acids.
Mercury
has been found to bind oxygen binding sites in hemoglobin, thus reducing access
to oxygen carried by the blood. (232,233,35,582) Oxyhemoglobin
saturation levels in venous blood should be at least 60% for normal levels. The
majority of a group of 27 patients with amalgam dental fillings suffering from
chronic fatigue whose oxyhemoglobin was tested had
lower than normal oxyhemoglobin saturation levels(232,35). After
amalgam replacement the majority of those with oxyhemoglobin
levels equal to or less than 45% had significant increases in oxyhemoglobin saturation levels, on average about 15%. Heme is used for 2 main functions, in red
blood cells and in production of energy by enzymatic processes in the ATP cytochrome oxidaze system. Mercury and other toxics have been documented
to block these enzymatic processes, resulting in dumping porphyrin
wastes into the urine rather than completing the proper heme functions. The level of these porphyrins
in the urine can be measured by a standard urine test, the fractionated porphrin test, and indicate the level of toxic disruption
of the basic enzymatic ATP production process.
The majority of the patients in the study had high levels of porphyrins in the urine, which decreased significantly
after amalgam replacement. This has also
been confirmed by other studies(260,233).
Mercury from amalgam binds to the -SH (sulfhydryl) groups, resulting in inactivation of sulfur and
blocking of enzyme functions such as cysteine dioxygenase(
Mercury has a high affinity for and readily binds
to selenium and to the thiol or sulfhydryl
(sulfur/hydrogen combination) sites in living tissues. The higher the
attraction between chemicals or elements, the stronger they bond to each other,
and the harder it is to separate them. The thiol
combination is extremely common in the human body. It occurs as part of certain
amino acids, which are building blocks of proteins. Since these amino acids are
used to build cells, hormones, and enzymes, the occurrence of the thiol combination in the body is not only common but
extremely important, as normal function is altered. There are several thiol sites in the hemoglobin molecule in the red blood
cells used to transport oxygen throughout the body. Mercury accumulates in red
blood cells in humans and other animals. When mercury attaches to the thiol sites, the hemoglobin can't carry as much oxygen as
it could. This results in decreased availability of oxygen (hypoxia)
that is needed by all body cells and explains one way that mercury toxicity can
cause chronic fatigue symptoms and other effects of low oxygen levels in the
cells.
Toxic metal exposure’s adverse influence on thyrocytes can play a major role in thyroid cancer etiology(144) .
Among those with chronic immune system problems with related immune
antibodies, the types showing the highest level of antibody reductions after
amalgam removal include
thyroglobulin and microsomal
thyroid antigens (91,369). Similar
results regarding
mercury have been found for treatment of other types of cancer. Studies have found conventional chemotherapy (alone)
to be only a little more effective than no treatment and clinical cases have
demonstrated that detoxification and nutritional support can be effective in treating multiple myeloma (550) and other cancers(486,530,35,228a).
Exposure
to mercury vapor causes decreased zinc and methionine
availability, depresses rates of methylation, and
increased free radicals- all factors in increased susceptibility to cancer
(14,34,38,43,143,144,180,237,239,251,256,283,530). Amalgam fillings have also been found to be
positively associated with oral cancer (206,251,403). Mercury from amalgam
fillings has also been found to cause increase in white blood cells and in some
cases to result in leukemia (35,180).
There is evidence that some forms of leukemia are abnormal response to
antigenic stimulation by mercury or other such toxics, and total dental
revision including removal of amalgam has led to remission very rapidly in some
cases (35,38,180,239).
Among a group of patients testing positive as allergic to mercury, low
level mercury exposure was found to cause adverse immune system response,
including effects on vitro production of tumor necrosis factor TNF alfa and reductions in interleukin-1. (126,131,152)
Mercury
has been found to cause decreased sperm volume and motility , increased sperm
abnormalities and spontaneous abortions, increased uterine fibroids/endometritis, and decreased fertility in animals (4,104,105,162)
and in humans (9,10,23,31,37,105,146,159, 395,433,27,35,38). In studies of women having miscarriages
or birth defects, husbands were found to typically have low sperm counts and
significantly more visually abnormal sperm(393). It's now estimated that up to
85 per cent of the sperm produced by a healthy male is
There
are extensive documented cases (many thousands) where removal of amalgam
fillings led to cure or significant improvement of serious health problems
such as oral keratosis
(pre cancer)(87,251), cancer (breast,leukemia,etc.)
(35,38,94,180,228a,469,486,487,530).
Some
studies have found increased risk of lung, kidney, brain, and
Some
studies have also found persons with chronic exposure to electromagnetic
fields(EMF) to have higher release of mercury from dental amalgam, higher levels
of mercury exposure and excretion (28,251c) and higher likelihood of getting
chronic conditions like
Mercury causes significant destruction
of stomach and intestine epithelial cells, resulting in damage to stomach lining which along with
mercury’s ability to bind to SH hydroxyl radical in cell membranes alters
permeability(338,405,35,21c) and adversely alters bacterial populations in the
intestines- causing leaky gut syndrome with toxic, incompletely digested
complexes in the blood(222,228b,35) and accumulation of heliobacter
pylori, a suspected major factor in
stomach ulcers and stomach cancer(256) and candida albicans(404),
as well as poor nutrient absorption.
From
extensive clinical experience the spread of cancer has been commonly found to
be related to fungal/Candida incidence, and treating Candida through blood
alkalinity balance and reduction of toxic metals body level has been found to
reduce the spread of cancer(233a). Such treatments also increase oxygen supply to
the cells. (580). An anaerobic environment favors the development of yeast
infections and cancer, since yeast is a fermenting spore and cancer is a
fermenting cell rather than a normal respiratory (oxygen using) cell.
Mercury
has a symbiotic relation to Candida in the body and promotes the proliferation
of Candida. Mercury impairs the body’s ability to kill Candida albicans by impairment of the lytic
activity of neutrophils and myeloperoxidase
in workers whose mercury excretion levels are within current safety limits(233,285,404).
Immune Th1 cells inhibit Candida by cytokine related activation of
macrophages and neutrophils. Development of Th2 type immune responses
deactivate such defenses(404b,181). Mercury inhibits
macrophage and neutrophil defense against Candida by
its affects on Th1 and Th2 cytokine effects(181,285,404b). Candida also methylates
inorganic mercury to the highly toxic methyl mercury form which like mercury
vapor readily crosses the blood-brain barrier, causes neurological damage, and
weakens the immune system ( 225,405 ) Candidiasis is often observed in immunocompromised individuals such as those with toxic
metal exposures, especially those who are found by test to be immune reactive
to mercury or other toxic metals (60,235,405). Amalgam replacement cures or significantly improves Candida (404,222,35,etc.),
Nickel and beryllium are 2 other metals
commonly used in dentistry that are very carcinogenic, toxic, and cause
Root
canals and cavitations also facilitate cancer by effect on immune system. (570) As more information is
accumulated it is apparent that these areas (bone cavitations) of chronic infection
in the craniofacial area are very real and the probable cause of multiple
painful conditions in the head, neck and tooth area. (571) This is due in part to the progressive loss
of vascularity in the jaw bones and associated structures. This allows the
pathogenic anaerobic microbial population to exist and create a chronic
infected, inflamed area. This area is effectively isolated from the circulatory
system which is responsible for delivering any anti-microbial medications to
the infected area. These types of bone cavities have also been shown to have
accumulations of toxic heavy metals, as well as the pathogenic microbes. There have been considerable numbers of cases
documented of recovery from cancer after dealing with oral infections such as
root canals and cavitations. (571,etc.)
Prostate
cancer is the most commonly diagnosed cancer in men in the
Cadmium
is a known human carcinogen and is linked to prostate cancer in epidemiologic
and laboratory animal studies (490,491). Food, cigarette smoke, and well water
are 3 sources of cadmium exposure. Toxic
metals such as mercury, lead, cadmium, and nickel have been found to promote
prostate cancer, and reducing toxic metal exposures and detoxification have
been found to cure or result in significant improvement in the condition (490,491,486,530,531,35).
Dietary
factors such as consumption level of red meat and environmental exposures to
estrogenic chemicals have been found to increase the incidence of both prostate
and breast cancer(490). Many occupational studies show
an increased incidence of prostate cancer incidence and/or mortality among
farmers and pesticide applicators. One
in vitro study of human prostate cancer cells showed that several organochlorine pesticides, a pyrethroid,
and a fungicide each caused proliferation of androgen-dependent cancer cells
(490). Another “environmental estrogen”, bisphenol A
(BPA-a component of epoxy resins, polycarbonate plastic, and dental sealants to
which the general population is exposed
at low levels), has been found to affect the prostate and be related to
development of prostate cancer(490).
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Case #3: A 51 year-old male presented with stage four squamous cell carcinoma located in the right pharyngeal-tonsil space. EG underwent conventional therapy with little to no success. Clinical exam revealed cavitational osteonecrotic lesion in the area of the lower right third molar. Soft tissue exam revealed swollen and inflamed pharyngeal arches, bilateral tonsilar inflammation and enlargement. Extraoral palpation revealed minor swelling of lymphatic nodes on the right side. Treatment goal was not to treat the cancer but to eradicate the infective state in the head and neck. EG was placed on a 3 month head and neck oxygen/ozone protocol developed by Dr. Mollica. This protocol was inclusive of direct and indirect infusion of 21 micograms/cc of oxygen/ozone into the afflicted areas. The afflicted areas being the osteonecrotic lesions, soft tissues, and lymphatic tissue. In addition to the oxygen/ozone therapy nu