Cancer Connection to Mercury, Toxic
Metals, and Dental Cavitations, with information on cancer treatment B Windham (Ed)
The President’s Cancer Panel Report
for 2008-2009 found that the true burden of environmentally induced cancers has
been grossly underestimated(547). Other
studies and documentation have similar findings(560).
As
seen here, in addition to cancers caused by radiation, pesticides, and other
organic chemicals, toxic metals such as mercury have major effects on weakening
the immune system and facilitating cancer.
Medical labs, medical studies, and
government agencies have documented that dental
amalgam is the largest source of mercury in most people who have several
amalgam fillings (1,500). Fish, vaccinations, and occupational exposure such as
dental offices are other sources of significant mercury exposures. A nationwide
survey found that over 22 percent of those tested for mercury levels in the
hair had dangerous levels higher than the U.S. EPA mercury health reference
level(2). Toxic
metal levels were measured in 6-24 hours urinary samples of 100 randomly chosen
patinets with chronic conditions at the Institute of Integrative Medicine
following a combined EDTA/DMSA provocation challenge. Over 70% had levels of lead, arsenic, mercury,
or cadmium outside the Laboratory Reference Level(571).
A large U.S. Centers for Disease Control
epidemiological study, NHANES
Mercury and other toxic metals such
as copper and lead cause breaks in
Nobel Prize winner Dr. Otto Warburg
determined that cancer has only one prime cause (581).
It is the replacement of normal oxygen respiration of the body's cells by an
anaerobic [i.e., oxygen-deficient] cell respiration. Porphyrins are precursors to heme, the oxygen carrying component of
blood. Mercury inhibits the
conversion of specific porphyrins to heme.
(84,35,201,539,500) Mercury has been documented to bind to oxygen carrying sites in
the blood, reducing a person’s available oxygen supply. (232,233,570,571,500). Mercury binds with hemoglobin, which is located inside the red
blood cell and carries oxygen for transport to tissues. Mercury bound to
hemoglobin results in less oxygen carrying capacity of the red blood cell and
therefore less oxygen will reach the tissues. The body senses the need for more
oxygen and may attempt to compensate for this by increasing the production of
hemoglobin. A normal or increased
hemoglobin level combined with symptoms of lack of oxygen (fatigue, weakness,
appearing pale, rapid heart rate, shortness of breath, etc) could indicate
mercury toxicity. But this can confuse some doctors since the patient seems
like they are anemic but in fact the blood counts seem fine (233). A new well documented book has more
information on causes of cancer and effective natural treatments for cancer(560), including the toxic teeth connection.
At
the energetic-molecular level, the boundary between health and the state of
absence of health is marked by oxidosis, acidosis, and dysoxygenosis (dysox).
(571,581) There is but one fundamental difference
between a healthy cell and an unwell cell: a healthy cell has a well preserved
oxygen homeostasis. A healthy cell utilizes oxygen well, without incremental
oxidative stress (oxidosis) and without accumulating
organic acids (acidosis). In contrast, an unwell cell
cannot utilize oxygen well and gets clogged up with Krebs cycle metabolites and
other organic acids. At the bioenergetic cellular
level, all inflammatory, autoimmune, and neurodegenerative disorders are caused
by the oxygen disorder (dysfunctional oxygen utilization) caused by cellular
toxicity in the cells.
Mercury
from dental amalgams appears to be one of the most, if not the most, potent
disrupters of oxygen metabolism in the oral cavity(571,233).
Other such disrupters are thioethers related to root canal teeth or cavitations
and other microbial toxins . Those factors also alter
the local conditions that either inhibit or foster microbial growth, so
facilitating biofilm formation. Such dynamics seem to play crucial roles in the
pathogenesis of systemic disorders rooted in the oral cavity. The crucial importance of oral toxicity in
triggering, amplifying, and perpetuating systemic inflammatory and infectious
disorders has largely been ignored by most doctors and dentists. The
presence of the cellular dysox state can be readily
documented by the measurement of 24-hour urinary excretion of organic acids.
Mercury has been found to bind
oxygen binding sites in hemoglobin, thus reducing access to oxygen carried by
the blood. (232,233,35,582) Oxyhemoglobin
saturation levels in venous blood should be at least 60% for normal levels. The
majority of a group of 27 patients with amalgam dental fillings suffering from
chronic fatigue whose oxyhemoglobin was tested had
lower than normal oxyhemoglobin saturation levels(232,35). After
amalgam replacement the majority of those with oxyhemoglobin
levels equal to or less than 45% had significant increases in oxyhemoglobin saturation levels, on average about 15%. Heme is used for 2 main functions, in red
blood cells and in production of energy by enzymatic processes in the ATP cytochrome oxidaze system. Mercury and other toxics have been documented
to block these enzymatic processes, resulting in dumping porphyrin
wastes into the urine rather than completing the proper heme functions. The level of these porphyrins
in the urine can be measured by a standard urine test, the fractionated porphrin test, and indicate the level of toxic disruption
of the basic enzymatic ATP production process.
The majority of the patients in the study had high levels of porphyrins in the urine, which decreased significantly
after amalgam replacement. This has also
been confirmed by other studies(260,233).
Mercury from amalgam binds to the
-SH (sulfhydryl) groups, resulting in inactivation of
sulfur and blocking of enzyme functions such as cysteine
dioxygenase(
Mercury
has a high affinity for and readily binds to selenium and to the thiol or sulfhydryl
(sulfur/hydrogen combination) sites in living tissues. The higher the
attraction between chemicals or elements, the stronger they bond to each other,
and the harder it is to separate them. The thiol
combination is extremely common in the human body. It occurs as part of certain
amino acids, which are building blocks of proteins. Since these amino acids are
used to build cells, hormones, and enzymes, the occurrence of the thiol combination in the body is not only common but
extremely important, as normal function is altered. There are several thiol sites in the hemoglobin molecule in the red blood
cells used to transport oxygen throughout the body. Mercury accumulates in red
blood cells in humans and other animals. When mercury attaches to the thiol sites, the hemoglobin can't carry as much oxygen as
it could. This results in decreased availability of oxygen (hypoxia)
that is needed by all body cells and explains one way that mercury toxicity can
cause chronic fatigue symptoms and other effects of low oxygen levels in the
cells.
Toxic metal exposure’s adverse
influence on thyrocytes can play a major role in
thyroid cancer etiology(144,500) . Among those with chronic immune system
problems with related immune antibodies, the types showing the highest level of
antibody reductions after amalgam removal include thyroglobulin
and microsomal thyroid antigens (91,369). Similar results regarding mercury have been found for treatment
of other types of cancer. Studies have
found conventional chemotherapy (alone) to be only a little more effective than
no treatment and clinical cases have demonstrated that detoxification and nutritional
support can be effective in treating
multiple myeloma (550) and other cancers(486,530,572,35,228a).
Exposure
to mercury vapor causes decreased zinc and methionine
availability, depresses rates of methylation, and
increased free radicals- all factors in increased susceptibility to cancer and
other chronic conditions (14,34,38,43,143,144,180,237,239,251,256,283, 530). Amalgam fillings have also been found to be
positively associated with oral cancer (206,251,403). Mercury from amalgam
fillings has also been found to cause increase in white blood cells and in some
cases to result in leukemia (35,180).
There is evidence that some forms of leukemia are abnormal response to
antigenic stimulation by mercury or other such toxics, and total dental
revision including removal of amalgam has led to remission very rapidly in some
cases (35,38,180,239,500). Among a group of patients testing positive as
allergic to mercury, low level mercury exposure was found to cause adverse
immune system response, including effects on vitro production of tumor necrosis
factor TNF alfa and reductions in interleukin-1.
(126,131,152)
Mercury has been found to cause
decreased sperm volume and motility , increased sperm abnormalities and
spontaneous abortions, increased uterine fibroids/endometritis,
and decreased fertility in animals (4,104,105,162) and in humans (9,10,23,31,37,105,146,159,
395,433,27,35,38). In
studies of women having miscarriages or birth defects, husbands
were found to typically have low sperm counts and significantly more visually
abnormal sperm(393). It's now estimated that up to 85 per cent of the sperm
produced by a healthy male is
There are extensive documented cases
(many thousands) where removal of amalgam fillings led to cure or significant improvement
of serious health problems such as oral keratosis (pre cancer)(87,251), cancer (breast,leukemia,etc.)
(35,38,94,180,228a,469,486,487,500, 530).
Some
studies have found increased risk of lung, kidney, brain, and
Some
studies have also found persons with chronic exposure to electromagnetic
fields(EMF) to have higher release of mercury from dental amalgam, higher levels
of mercury exposure and excretion (28,251c) and higher likelihood of getting
chronic conditions like
Mercury causes significant destruction
of stomach and intestine epithelial cells, resulting in damage to stomach lining which along with
mercury’s ability to bind to SH hydroxyl radical in cell membranes alters
permeability(338,405,35,21c) and adversely alters bacterial populations in the
intestines- causing leaky gut syndrome with toxic, incompletely digested
complexes in the blood(222,228b,35) and accumulation of heliobacter
pylori, a suspected major factor in
stomach ulcers and stomach cancer(256) and candida albicans(404),
as well as poor nutrient absorption.
From extensive clinical experience
the spread of cancer has been commonly found to be related to fungal/Candida
incidence, and treating Candida through blood alkalinity balance and reduction
of toxic metals body level has been found to reduce the spread of cancer(233a). Such
treatments also increase oxygen supply to the cells. (580). An anaerobic environment favors the development of yeast
infections and cancer, since yeast is a fermenting spore and cancer is a
fermenting cell rather than a normal respiratory (oxygen using) cell.
Mercury has a symbiotic relation to
Candida in the body and promotes the proliferation of Candida. Mercury impairs
the body’s ability to kill Candida albicans by
impairment of the lytic activity of neutrophils and myeloperoxidase
in workers whose mercury excretion levels are within current safety limits(233,285,404).
Immune Th1 cells inhibit Candida by cytokine related activation of
macrophages and neutrophils. Development of Th2 type immune responses
deactivate such defenses(404b,181). Mercury inhibits
macrophage and neutrophil defense against Candida by
its affects on Th1 and Th2 cytokine effects(181,285,404b). Candida also methylates
inorganic mercury to the highly toxic methyl mercury form which like mercury
vapor readily crosses the blood-brain barrier, causes neurological damage, and
weakens the immune system ( 225,405 ) Candidiasis is often
observed in immunocompromised individuals such as
those with toxic metal exposures, especially those who are found by test to be
immune reactive to mercury or other toxic metals (60,235,405). Amalgam replacement cures or
significantly improves Candida (404,222,35,etc.),
Nickel and beryllium are 2 other metals commonly
used in dentistry that are very carcinogenic, toxic, and cause
Root canals and cavitations also
facilitate cancer by effect on immune system. (570,560) As more
information is accumulated it is apparent that these areas (bone cavitations)
of chronic infection in the craniofacial area are very real and the probable
cause of multiple painful conditions in the head, neck and tooth area.
(571) This is
due in part to the progressive loss of vascularity in the jaw bones and
associated structures. This allows the pathogenic anaerobic microbial
population to exist and create a chronic infected, inflamed area. This area is
effectively isolated from the circulatory system which is responsible for
delivering any anti-microbial medications to the infected area. These types of
bone cavities have also been shown to have accumulations of toxic heavy metals,
as well as the pathogenic microbes.
There have been considerable numbers of cases documented of recovery
from cancer after dealing with oral infections such as root canals and
cavitations. (571,560,etc.)
Prostate
cancer is the most commonly diagnosed cancer in men in the
Cadmium and arsenic are known human
carcinogens and are linked to prostate & breast cancer in epidemiologic and
laboratory animal studies (490-494).
Cadmium and arsenic have also been found to be associated with lung cancer(491e,494c,etc.) Food, cigarette smoke, and well water are 3
sources of cadmium exposure. Selenium
(Se) in a large-scale human supplementation trial has been shown to
significantly reduce the incidence of prostate cancer in elderly men. Because
Se is known to interact with cadmium (Cd), it has
been suggested that its cancer protective action could be attributable in part
to its interaction with cadmium(11). The
excessive accumulation of Cd in the prostates of
smokers along with sub-optimal Se intakes could explain why smokers develop
more aggressive and lethal forms of prostate cancer than nonsmokers. Toxic
metals such as mercury, lead, cadmium, and nickel have been found to promote
prostate cancer, and reducing toxic metal exposures and detoxification with
nutritional support have been found to cure or result in significant
improvement in the condition (490,491,486,530,531,572,11,35).
Dietary
factors such as consumption level of red meat, refined carbohydrates, and
environmental exposures to estrogenic chemicals have been found to increase the
incidence of both prostate and breast cancer(490,560).
Many occupational studies show an increased incidence of prostate cancer
incidence and/or mortality among farmers and pesticide applicators. One in vitro study of human prostate cancer
cells showed that several organochlorine pesticides,
a pyrethroid, and a fungicide each caused
proliferation of androgen-dependent cancer cells (490). Another “environmental
estrogen”, bisphenol A (BPA-a component of epoxy
resins, polycarbonate plastic, and dental sealants to which the general
population is exposed
at low levels), has been found to affect the prostate and be related to
development of prostate cancer(490).
The
toxic metals mercury, lead, cadmium, copper, cobalt, nickel, lead, aluminum, and
tin have been found to have reproductive and endocrine system disrupting
effects(10,12), as well as synergistic
effects. The
ability of metals to activate estrogen receptor-alpha (ERalpha)
was measured in the human breast cancer cell line, MCF-7. Similar to estradiol, treatment of cells with the divalent metals
copper, cobalt, nickel, lead, mercury, tin, and chromium or with the metal
anion vanadate stimulated cell proliferation; by day
6, there was a 2- to 5-fold increase in cell number. The metals also decreased
the concentration of ERalpha protein and mRNA by
40-60% and induced expression of the estrogen-regulated genes progesterone
receptor and pS2 by1.6- to 4-fold. Furthermore, there was a 2- to 4-fold
increase in chloramphenicol acetyltransferase
activity after treatment with the metals in COS-1 cells transiently cotransfected with the wild-type receptor and an
estrogen-responsive chloramphenicol acetyltransferase reporter gene. The ability of the metals
to alter gene expression was blocked by an antiestrogen,
suggesting that the activity of these compounds is mediated by ERalpha(10,12). Aluminium in the form of aluminium
chloride or aluminium chlorhydrate,
which are used in antiperspirants, can interfere with the function of oestrogen receptors of MCF7 human breast cancer cells both
in terms of ligand binding and in terms of oestrogen-regulated reporter gene expression(12).
Cancer
Treatments
As previously seen, there are several estrogenic
or carcinogenic metals, and clinical experience has found metals detoxification
to be beneficial in cancer case treatment.
There are also diet measures and supplements that have been found to be
beneficial in preventing or treating cancer. A comprehensive and well
documented summary of natural cancer treatments clinically documented to be
effective in treating cancer is Outsmarting Your Cancer (560). Many
effective options are covered, with considerable detail and documentation.
Vit K2, Vit D, zinc, and green tea have all been found to be
effective in preventing or treatment of prostate cancer and other types of cancer(501-503,493a). Black tea theaflavins
have been found to be effective at prevention of cigarette smoke-induced
lung damage and cancer(504), and have demonstrated effectiveness in switching
off the genes involved in many types of cancer(505). Studies have shown theaflavin supplementation significantly reduces levels of
inflammatory cytokines such as TNF-alpha, Il-6, Il-8, and C-reactive protein;
and lowered rates of production of inflammation-generating trasnscription
factor NF-kB, cytokine generating COX-2, and the
adhesion molecule ICAM-1(506). Vitamin K2 has been shown to induce apoptosis in
leukemia cells in vitro and inhibitory effects against myeloma and lymphoma, as
well as being effective at reducing liver cancer in patients with hepatitis B
or C(known risk factors for liver cancer), and also to
be effective at reducing rate of re-occurrence of liver cancer in liver cancer
patients in remission(506). Apatone (Vit C & Vit K3) was demonstrated to significantly delay cancer
progression in a group of end stage prostate cancer patients.
Patients
with advanced cancer have been found to be vitamin K deficient and it is
recommended to monitor levels and supplement where needed(506). Several studies found evidence of benefit of
intravenous Vit C in treatment of cancer(15).
A connection between cancer and fungus/candida has been demonstrated and many types of cancers
have been successfully treated using sodium bicarbonate (551,552). Magnesium and Iodine have also been found
beneficial in treating cancer(552) and flax oil with
cottage cheese which addresses common digestive problems that can be related to
cancer (553). Supplementation with chlorella has been found to result in
beneficial effects when used in cancer patients or for other chronic conditions
such as ulcerative colitis, hypertention, or Fibromyalgia(572). Doctors such as D. Klinghardt
have suggested that the mechanism by which chlorella improves treatment of such
conditions is metals detoxification, which is the main mechanism of action of
chlorella.
People who drink two or more high
fructose syrup sweetened soft drinks a week have a much higher (87%) risk of
pancreatic cancer. The high levels of sugar in soft drinks may be increasing
the level of insulin in the body, which the authors think contributes to
pancreatic cancer cell growth(495).
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Case #3: A 51 year-old male presented
with stage four squamous cell
carcinoma located in the right pharyngeal-tonsil space. EG underwent
conventional therapy with little to no success. Clinical exam revealed cavitational osteonecrotic lesion
in the area of the lower right third molar. Soft tissue exam revealed swollen
and inflamed pharyngeal arches, bilateral tonsilar
inflammation and enlargement. Extraoral palpation
revealed minor swelling of lymphatic nodes on the right side. Treatment goal
was not to treat the cancer but to eradicate the infective state in the head
and neck. EG was placed on a 3 month head and neck oxygen/ozone protocol
developed by Dr. Mollica. This protocol was inclusive
of direct and indirect infusion of 21 micograms/cc of
oxygen/ozone into the afflicted areas. The afflicted areas
being the osteonecrotic lesions, soft tissues, and
lymphatic tissue. In addition to the oxygen/ozone therapy nutritional
and drainage support was provided. Within a month after the completion of the
protocol EG was given an exam which included a PET scan. No trace of the cancer
or any activity associated with the lesion was found. Attributed
to spontaneous remission.