Cancer
Connection to Mercury, Toxic Metals, and Dental Cavitations B
The
President’s Cancer Panel Report for 2008-2009 found that the true burden of
environmentally induced cancers has been grossly underestimated(547). As
seen here, in addition to cancers caused by radiation, pesticides, and other
organic chemicals, toxic metals such as mercury have major effects on weakening
the immune system and facilitating cancer.
Medical
labs, medical studies, and government agencies have documented that dental
amalgam is the largest source of mercury in most people who have several
amalgam fillings (1). Fish, vaccinations, and occupational exposure such as
dental offices are other sources of significant mercury exposures. A nationwide
survey found that over 22 percent of those tested for mercury levels in the
hair had dangerous levels higher than the U.S. EPA mercury health reference
level(2). Toxic
metal levels were measured in 6-24 hours urinary samples of 100 randomly chosen
patinets with chronic conditions at the Institute of Integrative Medicine
following a combined EDTA/DMSA provocation challenge. Over 70% had levels of lead, arsenic,
mercury, or cadmium outside the Laboratory Reference Level(571).
A large U.S. Centers for Disease Control
epidemiological study, NHANES
Mercury
and other toxic metals such as copper and lead cause breaks in
Nobel
Prize winner Dr. Otto Warburg determined that cancer
has only one prime cause (581). It is the replacement of normal oxygen
respiration of the body's cells by an anaerobic [i.e., oxygen-deficient] cell
respiration. Porphyrins are precursors to heme,
the oxygen carrying component of blood. Mercury
inhibits the conversion of specific porphyrins to heme.
(84,35,201,539) Mercury has been documented to bind to oxygen carrying sites in
the blood, reducing a person’s available oxygen supply. (232,233,570,571). Mercury binds with hemoglobin, which is located inside the red
blood cell and carries oxygen for transport to tissues. Mercury bound to
hemoglobin results in less oxygen carrying capacity of the red blood cell and
therefore less oxygen will reach the tissues. The body senses the need for more
oxygen and may attempt to compensate for this by increasing the production of
hemoglobin. A normal or increased
hemoglobin level combined with symptoms of lack of oxygen (fatigue, weakness,
appearing pale, rapid heart rate, shortness of breath, etc) could indicate
mercury toxicity. But this can confuse some doctors since the patient seems
like they are anemic but in fact the blood counts seem fine (233).
At the
energetic-molecular level, the boundary between health and the state of absence
of health is marked by oxidosis, acidosis, and dysoxygenosis (dysox). (571,581) There is but one fundamental difference
between a healthy cell and an unwell cell: a healthy cell has a well preserved
oxygen homeostasis. A healthy cell utilizes oxygen well, without incremental
oxidative stress (oxidosis) and without accumulating
organic acids (acidosis). In contrast, an unwell cell
cannot utilize oxygen well and gets clogged up with Krebs cycle metabolites and
other organic acids. At the bioenergetic cellular
level, all inflammatory, autoimmune, and neurodegenerative disorders are caused
by the oxygen disorder (dysfunctional oxygen utilization) caused by cellular
toxicity in the cells.
Mercury from dental
amalgams appears to be one of the most, if not the most, potent disrupters of
oxygen metabolism in the oral cavity(571,233). Other
such disrupters are thioethers related to root canal teeth or cavitations and
other microbial toxins . Those factors also alter the
local conditions that either inhibit or foster microbial growth, so
facilitating biofilm formation. Such dynamics seem to play crucial roles in the
pathogenesis of systemic disorders rooted in the oral cavity. The crucial importance of oral toxicity in
triggering, amplifying, and perpetuating systemic inflammatory and infectious
disorders has largely been ignored by most doctors and dentists. The
presence of the cellular dysox state can be readily
documented by the measurement of 24-hour urinary excretion of organic acids.
Mercury
has been found to bind oxygen binding sites in hemoglobin, thus reducing access
to oxygen carried by the blood. (232,233,35,582) Oxyhemoglobin
saturation levels in venous blood should be at least 60% for normal levels. The
majority of a group of 27 patients with amalgam dental fillings suffering from
chronic fatigue whose oxyhemoglobin was tested had
lower than normal oxyhemoglobin saturation levels(232,35). After
amalgam replacement the majority of those with oxyhemoglobin
levels equal to or less than 45% had significant increases in oxyhemoglobin saturation levels, on average about 15%. Heme is used for 2 main functions, in red
blood cells and in production of energy by enzymatic processes in the ATP cytochrome oxidaze system. Mercury and other toxics have been documented
to block these enzymatic processes, resulting in dumping porphyrin
wastes into the urine rather than completing the proper heme functions. The level of these porphyrins
in the urine can be measured by a standard urine test, the fractionated porphrin test, and indicate the level of toxic disruption
of the basic enzymatic ATP production process.
The majority of the patients in the study had high levels of porphyrins in the urine, which decreased significantly
after amalgam replacement. This has also
been confirmed by other studies(260,233).
Mercury from amalgam binds to the
-SH (sulfhydryl) groups, resulting in inactivation of
sulfur and blocking of enzyme functions such as cysteine
dioxygenase(
Mercury has a high affinity for and readily binds
to selenium and to the thiol or sulfhydryl
(sulfur/hydrogen combination) sites in living tissues. The higher the
attraction between chemicals or elements, the stronger they bond to each other,
and the harder it is to separate them. The thiol
combination is extremely common in the human body. It occurs as part of certain
amino acids, which are building blocks of proteins. Since these amino acids are
used to build cells, hormones, and enzymes, the occurrence of the thiol combination in the body is not only common but
extremely important, as normal function is altered. There are several thiol sites in the hemoglobin molecule in the red blood
cells used to transport oxygen throughout the body. Mercury accumulates in red
blood cells in humans and other animals. When mercury attaches to the thiol sites, the hemoglobin can't carry as much oxygen as
it could. This results in decreased availability of oxygen (hypoxia)
that is needed by all body cells and explains one way that mercury toxicity can
cause chronic fatigue symptoms and other effects of low oxygen levels in the
cells.
Toxic metal exposure’s adverse
influence on thyrocytes can play a major role in
thyroid cancer etiology(144) . Among those with chronic immune system
problems with related immune antibodies, the types showing the highest level of
antibody reductions after amalgam removal include thyroglobulin
and microsomal thyroid antigens (91,369). Similar results regarding mercury have been found for treatment
of other types of cancer. Studies have
found conventional chemotherapy (alone) to be only a little more effective than
no treatment and clinical cases have demonstrated that detoxification and nutritional
support can be effective in treating
multiple myeloma (550) and other cancers(486,530,572,35,228a).
Exposure
to mercury vapor causes decreased zinc and methionine
availability, depresses rates of methylation, and
increased free radicals- all factors in increased susceptibility to cancer
(14,34,38,43,143,144,180,237,239,251,256,283,530). Amalgam fillings have also been found to be
positively associated with oral cancer (206,251,403). Mercury from amalgam
fillings has also been found to cause increase in white blood cells and in some
cases to result in leukemia (35,180).
There is evidence that some forms of leukemia are abnormal response to
antigenic stimulation by mercury or other such toxics, and total dental
revision including removal of amalgam has led to remission very rapidly in some
cases (35,38,180,239).
Among a group of patients testing positive as allergic to mercury, low
level mercury exposure was found to cause adverse immune system response,
including effects on vitro production of tumor necrosis factor TNF alfa and reductions in interleukin-1. (126,131,152)
Mercury
has been found to cause decreased sperm volume and motility , increased sperm
abnormalities and spontaneous abortions, increased uterine fibroids/endometritis, and decreased fertility in animals (4,104,105,162)
and in humans (9,10,23,31,37,105,146,159, 395,433,27,35,38). In studies of women having miscarriages
or birth defects, husbands were found to typically have low sperm counts and
significantly more visually abnormal sperm(393). It's now estimated that up to
85 per cent of the sperm produced by a healthy male is
There
are extensive documented cases (many thousands) where removal of amalgam
fillings led to cure or significant improvement of serious health problems
such as oral keratosis
(pre cancer)(87,251), cancer (breast,leukemia,etc.)
(35,38,94,180,228a,469,486,487,530).
Some
studies have found increased risk of lung, kidney, brain, and
Some
studies have also found persons with chronic exposure to electromagnetic
fields(EMF) to have higher release of mercury from dental amalgam, higher levels
of mercury exposure and excretion (28,251c) and higher likelihood of getting
chronic conditions like
Mercury causes significant destruction
of stomach and intestine epithelial cells, resulting in damage to stomach lining which along with
mercury’s ability to bind to SH hydroxyl radical in cell membranes alters
permeability(338,405,35,21c) and adversely alters bacterial populations in the
intestines- causing leaky gut syndrome with toxic, incompletely digested
complexes in the blood(222,228b,35) and accumulation of heliobacter
pylori, a suspected major factor in
stomach ulcers and stomach cancer(256) and candida albicans(404),
as well as poor nutrient absorption.
From
extensive clinical experience the spread of cancer has been commonly found to
be related to fungal/Candida incidence, and treating Candida through blood
alkalinity balance and reduction of toxic metals body level has been found to
reduce the spread of cancer(233a). Such treatments also increase oxygen supply
to the cells. (580). An anaerobic environment favors the development of yeast
infections and cancer, since yeast is a fermenting spore and cancer is a
fermenting cell rather than a normal respiratory (oxygen using) cell.
Mercury
has a symbiotic relation to Candida in the body and promotes the proliferation
of Candida. Mercury impairs the body’s ability to kill Candida albicans by impairment of the lytic
activity of neutrophils and myeloperoxidase
in workers whose mercury excretion levels are within current safety limits(233,285,404).
Immune Th1 cells inhibit Candida by cytokine related activation of
macrophages and neutrophils. Development of Th2 type immune responses
deactivate such defenses(404b,181). Mercury inhibits
macrophage and neutrophil defense against Candida by
its affects on Th1 and Th2 cytokine effects(181,285,404b). Candida also methylates
inorganic mercury to the highly toxic methyl mercury form which like mercury
vapor readily crosses the blood-brain barrier, causes neurological damage, and
weakens the immune system ( 225,405 ) Candidiasis is often
observed in immunocompromised individuals such as
those with toxic metal exposures, especially those who are found by test to be
immune reactive to mercury or other toxic metals (60,235,405). Amalgam replacement cures or
significantly improves Candida (404,222,35,etc.),
Nickel and beryllium are 2 other metals
commonly used in dentistry that are very carcinogenic, toxic, and cause
Root
canals and cavitations also facilitate cancer by effect on immune system. (570) As more
information is accumulated it is apparent that these areas (bone cavitations)
of chronic infection in the craniofacial area are very real and the probable
cause of multiple painful conditions in the head, neck and tooth area.
(571) This is
due in part to the progressive loss of vascularity in the jaw bones and
associated structures. This allows the pathogenic anaerobic microbial
population to exist and create a chronic infected, inflamed area. This area is
effectively isolated from the circulatory system which is responsible for
delivering any anti-microbial medications to the infected area. These types of
bone cavities have also been shown to have accumulations of toxic heavy metals,
as well as the pathogenic microbes.
There have been considerable numbers of cases documented of recovery
from cancer after dealing with oral infections such as root canals and
cavitations. (571,etc.)
Prostate
cancer is the most commonly diagnosed cancer in men in the
Cadmium and arsenic are known human
carcinogens and are linked to prostate & breast cancer in epidemiologic and
laboratory animal studies (490-494).
Cadmium and arsenic have also been found to be associated with lung cancer(491e,494c,etc.) Food, cigarette smoke, and well water are 3
sources of cadmium exposure. Selenium
(Se) in a large-scale human supplementation trial has been shown to
significantly reduce the incidence of prostate cancer in elderly men. Because
Se is known to interact with cadmium (Cd), it has
been suggested that its cancer protective action could be attributable in part
to its interaction with cadmium(11). The
excessive accumulation of Cd in the prostates of
smokers along with sub-optimal Se intakes could explain why smokers develop
more aggressive and lethal forms of prostate cancer than nonsmokers. Toxic
metals such as mercury, lead, cadmium, and nickel have been found to promote
prostate cancer, and reducing toxic metal exposures and detoxification with
nutritional support have been found to cure or result in significant
improvement in the condition (490,491,486,530,531,572,11,35).
Dietary
factors such as consumption level of red meat and environmental exposures to
estrogenic chemicals have been found to increase the incidence of both prostate
and breast cancer(490). Many occupational studies show
an increased incidence of prostate cancer incidence and/or mortality among
farmers and pesticide applicators. One
in vitro study of human prostate cancer cells showed that several organochlorine pesticides, a pyrethroid,
and a fungicide each caused proliferation of androgen-dependent cancer cells
(490). Another “environmental estrogen”, bisphenol A
(BPA-a component of epoxy resins, polycarbonate plastic, and dental sealants to
which the general population is exposed
at low levels), has been found to affect the prostate and be related to
development of prostate cancer(490).
The
toxic metals mercury, lead, cadmium, copper, cobalt, nickel, lead, aluminum, and
tin have been found to have reproductive and endocrine system disrupting
effects(10,12), as well as synergistic
effects. The
ability of metals to activate estrogen receptor-alpha (ERalpha)
was measured in the human breast cancer cell line, MCF-7. Similar to estradiol, treatment of cells with the divalent metals
copper, cobalt, nickel, lead, mercury, tin, and chromium or with the metal
anion vanadate stimulated cell proliferation; by d 6,
there was a 2- to 5-fold increase in cell number. The metals also decreased the
concentration of ERalpha protein and mRNA by 40-60%
and induced expression of the estrogen-regulated genes progesterone receptor
and pS2 by1.6- to 4-fold. Furthermore, there was a 2- to 4-fold increase in chloramphenicol acetyltransferase
activity after treatment with the metals in COS-1 cells transiently cotransfected with the wild-type receptor and an
estrogen-responsive chloramphenicol acetyltransferase reporter gene. The ability of the metals
to alter gene expression was blocked by an antiestrogen,
suggesting that the activity of these compounds is mediated by ERalpha(10,12). Aluminium in the form of aluminium
chloride or aluminium chlorhydrate,
which are used in antiperspirants, can interfere with the function of oestrogen receptors of MCF7 human breast cancer cells both
in terms of ligand binding and in terms of oestrogen-regulated reporter gene expression(12).
Cancer
Treatments
As previously seen, there are several estrongenic or carciagenic
metals, and clinical experience has found metals detoxification to be
beneficial in cancer case treatment.
There are also diet measures and supplements that have been found to be
beneficial in preventing or treating cancer.
Vit K2, Vit D, zinc, and green tea have all been found to be effective in preventing or treatment of prostate cancer and other types of cancer(501-503,493a). Black tea theaflavins have been found to be effective at prevention of cigarette smoke-induced lung damage and cancer(504), and have demonstrated effectiveness in switching off the genes involved in many types of cancer(505). Studies have shown theaflavin supplementation significantly reduces levels of inflammatory cytokines such as TNF-alpha, Il-6, Il-8, and C-reactive protein; and lowered rates of production of inflammation-generating trasnscription factor NF-kB, cytokine generating COX-2, and the adhesion molecule ICAM-1(506). Vitamin K2 has been shown to induce apoptosis in leukemia cells in vitro and inhibitory effects against myeloma and lymphoma, as well as being effective at reducing liver cancer in patients with hepatitis B or C(known risk factors for liver cancer), and also to be effective at reducing rate of re-occurrence of liver cancer in liver cancer patients in remission(506). Apatone (Vit C & Vit K3) was demonstrated to significantly delay cancer progression in a group of end stage prostate cancer patients.
Patients with advanced cancer have been found to be vitamin K deficient and it is recommended to monitor levels and supplement where needed(506). Several studies found evidence of benefit of intravenous Vit C in treatment of cancer(15). A connection between cancer and fungus/candida has been demonstrated and many types of cancers have been successfully treated using sodium bicarbonate (551,552). Magnesium and Iodine have also been found beneficial in treating cancer(552) and flax oil with cottage cheese which addresses common digestive problems that can be related to cancer (553). Supplementation with chlorella has been found to result in beneficial effects when used in cancer patients or for other chronic conditions such as ulcerative colitis, hypertention, or Fibromyalgia(572). Doctors such as D. Klinghardt have suggested that the mechanism by which chlorella improves treatment of such conditions is metals detoxification, which is the main mechanism of action of chlorella.
People who drink two or more high
fructose syrup sweetened soft drinks a week have a much higher (87%) risk of
pancreatic cancer. The high levels of sugar in soft drinks may be increasing
the level of insulin in the body, which the authors think contributes to
pancreatic cancer cell growth(495).
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Case #3: A 51 year-old male presented with stage four squamous cell carcinoma
located in the right pharyngeal-tonsil space. EG underwent conventional therapy
with little to no success. Clinical exam revealed cavitational
osteonecrotic lesion in the area of the lower right
third molar. Soft tissue exam revealed swollen and inflamed pharyngeal arches,
bilateral tonsilar inflammation and enlargement. Extraoral palpation revealed minor swelling of lymphatic
nodes on the right side. Treatment goal was not to treat the cancer but to
eradicate the infective state in the head and neck. EG was placed on a 3 month
head and neck oxygen/ozone protocol developed by Dr. Mollica.
This protocol was inclusive of direct and indirect infusion of 21 micograms/cc of oxygen/ozone into the afflicted areas. The afflicted areas being the osteonecrotic
lesions, soft tissues, and lymphatic tissue. In addition to the
oxygen/ozone therapy nutritional and drainage support was provided. Within a
month after the completion of the protocol EG was given an exam which included
a PET scan. No trace of the cancer or any activity associated with the lesion
was found. Attributed to spontaneous remission.